Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo
نویسندگان
چکیده
منابع مشابه
Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.
BACKGROUND Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke risk. METHODS AND RESULTS We recently developed a genetic mouse model...
متن کاملStroke Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo
Background—Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with plateletdependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke risk. Methods and Results—We recently developed a genetic mouse model to...
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ژورنال
عنوان ژورنال: Circulation
سال: 2011
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.110.000034